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Effect of chronic administration of U-50,488H, a κ-opioid receptor agonist, on central dopamine D2 receptors of the rat

✍ Scribed by Veeranna; Poluru L. Reddy; Hemendra N. Bhargava

Book ID
115888891
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
636 KB
Volume
235
Category
Article
ISSN
0014-2999

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✍ Sanders A. McDougall; Audrey L. Rodarte-Freeman; Arbi Nazarian 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 144 KB 👁 1 views

## Opioid receptor agonists (e.g.,488) increase the locomotor activity of preweanling rats, while the same drugs depress the locomotor activity of adults. Curiously, direct stimulation of dopamine (DA) D 2 -like receptors fully attenuates the U-50,488-induced locomotor activity of preweanling rats