Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein
✍ Scribed by Carolina I Ghanem; Paula C Gómez; Marı́a C Arana; Marı́a Perassolo; Marı́a L Ruiz; Silvina S.M Villanueva; Elena J Ochoa; Viviana A Catania; Laura A Bengochea; Aldo D Mottino
- Book ID
- 113487238
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 293 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0006-2952
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Although it has been well established that the drug efflux pump P-glycoprotein (P-gp) protects the brain against the entry of cytotoxic drugs, its real in situ localization, i.e., at brain capillary endothelial cells or on astrocyte foot processes, is still controversial. The aim of this study was t
## Abstract The multidrug transporter P‐glycoproteins are encoded by three multidrug‐resistance (__mdr__) genes in rodents, designated __mdr1a__ (__mdr3__), __mdr1b__ (__mdr1__), and __mdr2.__ Only the first two genes are functionally related to multidrug resistance. Activation of rodent __mdr__ ge