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Effect of a selective dopamine D1 agonist (ABT-431) on smoked cocaine self-administration in humans

โœ Scribed by M. Haney; Eric D. Collins; Amie S. Ward; Richard W. Foltin; Marian W. Fischman


Publisher
Springer
Year
1999
Tongue
English
Weight
191 KB
Volume
143
Category
Article
ISSN
0033-3158

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An array of evidence indicates that long-term exposure to cocaine alters several components of the brain dopamine system. Because the release of dopamine in the nucleus accumbens (NAc) has been implicated in mediating the reinforcing effects of cocaine, changes in dopamine function can have profound

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The present study used autoradiography to examine the effects of chronic self-administration of cocaine on the density of dopamine D 2 receptors in nonhuman primates. Three rhesus monkeys intravenously self-administered an average of 1.35 mg/kg cocaine per day for 18-22 months until they were euthan