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Effect of a pyruvate kinase (pykF-gene) knockout mutation on the control of gene expression and metabolic fluxes in Escherichia coli

โœ Scribed by Khandaker Al Zaid Siddiquee; Marcos J. Arauzo-Bravo; Kazuyuki Shimizu


Book ID
116467153
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
472 KB
Volume
235
Category
Article
ISSN
0378-1097

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In a previous study, an Escherichia coli strain lacking the key enzymes (acetate kinase and phosphotransacetylase, ACK-PTA) of the major acetate synthesis pathways reduced acetate accumulation. The ackA-pta mutant strain also exhibits an increased lactate synthesis rate. Metabolic flux analysis sugg