The pharmacokinetics of 3-(decyldimethylsilyI)-N-[2-(4-methylphenyl)-lphenylethyllpropanamide (DMPP), an inhibitor of acyl-CoA:cholesterol acyltransferase, have been studied in the dog and the rat using "C and 'H dual-labelled drug. In both species, gastrointestinal absorption of DMPP was slow and
Effect of a dispersion of cholesterol in Triton WR-1339 on acyl CoA: Cholesterol acyltransferase in rat liver microsomes
โ Scribed by Jeffrey T. Billheimer; Deebeanne Tavani; William R. Nes
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 366 KB
- Volume
- 111
- Category
- Article
- ISSN
- 0003-2697
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Previous studies have shown that rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) show signs of toxicity that are similar to the responses of animals to a vitamin A-deficient diet. These include hypophagia, loss of body weight, loss of hepatic vitamin A, and accumulation of renal retinoi