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Effect of a coat color locus on kidney lysosomal glycosidases in the house mouse

✍ Scribed by Eva M. H»kansson; Lars-G. Lundin

Publisher
Springer
Year
1977
Tongue
English
Weight
394 KB
Volume
15
Category
Article
ISSN
0006-2928

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✦ Synopsis

Activities of three lysosomal glycosidases, fl-galactosidase, fl-glucuronidase, and N-acetyl-fl-hexosaminidase, have been shown to differ in .bf/bf and bf/+ mice. Thus bf/bf mice usually have much higher activities of these enzymes in their kidney cells than bf/+ animals. There seem, however, to be some exceptions to this general pattern, especially for galactosidase of females from the C57BL/6J strain. A likely interpretation of the difference is that the bf locus has pleiotropie effects. An alternative explanation, less likely, is that a gene closely linked to bf is involved. There is also a differential response to dihydrotestosterone in different groups of mice reflected in activity changes of the three enzymes.

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