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Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver

✍ Scribed by José Gómez; Pilar Caro; Alba Naudí; Manuel Portero-Otin; Reinald Pamplona; Gustavo Barja

Publisher: Springer
Year: 2007
Tongue: English
Weight: 316 KB
Volume: 8
Category: Article
ISSN: 1389-5729
DOI: 10.1007/s10522-007-9099-1

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## Abstract In the present study, the question if medium‐term (4 months) caloric restriction (40%) decreases mitochondrial H~2~O~2~ production and oxidative DNA damage was investigated. Caloric restriction (CR) is the only experimental manipulation that increases maximum life span. Previous long‐te