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Effect of 5-bromodeoxyuridine on the appearance of cytoplasmic poly-A containing RNA

✍ Scribed by Philip J. Pawlowski

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
568 KB
Volume
89
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Cytoplasmic poly‐A containing RNA, synthesized by cultured chick embryo cells, was examined during growth in 5‐bromodeoxyuridine. The kinetics of ^3^H‐adenosine incorporation into this species of RNA, when compared to the rest of the cytoplasmic RNA, and to control cells, indicates that the rate of synthesis of this RNA is slower in BrdU treated cells. An examination of the rate at which a steady state distribution of radioactivity, between the poly‐A segment and non‐poly‐A portion of poly‐A containing RNA is reached also indicated that this species is synthesized at a lower rate in BrdU treated cells.

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