Editorial: Role of cyclin-dependent kinase-5 (Cdk5) in the central nervous system
โ Scribed by Marc Blondel; Laurent Meijer
- Book ID
- 112011646
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 191 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1860-6768
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Cyclin-dependent kinase 5 (Cdk5) is a member of the cyclin-dependent kinase family that is involved in the regulation of the cell cycle. As their name suggests, the Cdks require association with activator proteins called cyclins for their activity. Cdk5, however, is unique to this family of proline-
The ubiquitously expressed cyclinzone, which may restrict cdk5 activation to the postmidependent kinase 5 (cdk5) is essential for brain develtotic neural cells in the developing brain. The expresopment. Bioactivation of cdk5 in the brain requires sion levels of p35 and p39 mRNAs in the marginal the