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Eculizumab, a terminal complement inhibitor, improves anaemia in patients with paroxysmal nocturnal haemoglobinuria

✍ Scribed by Jörg Schubert; Peter Hillmen; Alexander Röth; Neal S. Young; Modupe O. Elebute; Jeffrey Szer; Giacomo Gianfaldoni; Gérard Socié; Paul Browne; Robert Geller; Russell P. Rother; Petra Muus


Book ID
108675796
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
197 KB
Volume
142
Category
Article
ISSN
0007-1048

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## Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a debilitating and life‐threatening disease in which lysis of PNH red blood cells frequently manifests with chronic hemolysis, anemia, and thrombosis. Renal damage in PNH is associated with chronic hemosiderosis and/or microvascular thrombosi