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Antiphospholipid antibodies in patients with paroxysmal nocturnal haemoglobinuria receiving eculizumab

✍ Scribed by Luc Darnige; Régis Peffault de Latour; Laurence Zemori; Gérard Socié; Anne-Marie Fischer; Dominique Helley; on behalf of the French Society of Haematology


Book ID
108677247
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
114 KB
Volume
153
Category
Article
ISSN
0007-1048

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Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired hemolytic anemia caused by somatic mutations in the phosphatidylinositol glycan-complementation class A gene and the resulting absence of a key complement regulatory protein, CD59. Affected red blood cells in patients with PNH undergo int