Ectyoplasides A–B – Unique Triterpene Oligoglycosides from the Caribbean Sponge Ectyoplasia ferox

✍ Scribed by Francesco Cafieri; Ernesto Fattorusso; Orazio Taglialatela-Scafati

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 186 KB
• Volume: 1999
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/(sici)1099-0690(199901)1999:1<231::aid-ejoc231>3.0.co;2-u

✦ Synopsis

Two novel norlanostane triglycosides, ectyoplasides A (1) been shown to possess identical sugar chains (composed of two β-galactose units and one α-arabinose unit), but to differ and B (2), have been isolated from the methanolic extracts of the Caribbean sponge Ectyoplasia ferox (Raspaliidae, in their aglycone moieties, which possess nortriterpene skeletons with an unprecedented substitution pattern on ring Axinellida). Their structures have been established by extensive application of high-resolution FABMS and two-A. Ectyoplasides A and B show moderate cytotoxic activity when tested in vitro towards various cell lines dimensional NMR techniques, supported by chemical and enzymatic degradation methods. Ectyoplasides A and B have dition, 1 and 2 possess an invariant triglycosidic chain as a