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Ectopic induction of cartilage and bone by water-soluble proteins from bovine bone using a polyanhydride delivery vehicle

โœ Scribed by Lucas, Paul A. ;Laurencin, Cato ;Syftestad, Glenn T. ;Domb, Abraham ;Goldberg, Victor M. ;Caplan, Arnold I. ;Langer, Robert


Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
817 KB
Volume
24
Category
Article
ISSN
0021-9304

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Two kinds of bone morphogenetic protein (BMP) containing polymeric reservoirs made from poly(1actide-coglycolide) (PLG) and a mixture of PLGipoly(ethy1ene glycol) (PEG) (PLGPEG) were implanted into mice femoral muscles. In the PLGiPEG reservoir with BMP, bone formation was induced within 3 weeks. On