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Ectopic induction of cartilage and bone by bovine bone morphogenetic protein using a biodegradable polymeric reservoir

✍ Scribed by Yamazaki, Yasuharu ;Oida, Shin-ichiro ;Ishihara, Kazuhiko ;Nakabayashi, Nobuo

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 471 KB
Volume: 30
Category: Article
ISSN: 0021-9304
DOI: 10.1002/(sici)1097-4636(199601)30:1<1::aid-jbm1>3.0.co;2-w

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✦ Synopsis

Two kinds of bone morphogenetic protein (BMP) containing polymeric reservoirs made from poly(1actide-coglycolide) (PLG) and a mixture of PLGipoly(ethy1ene glycol) (PEG) (PLGPEG) were implanted into mice femoral muscles. In the PLGiPEG reservoir with BMP, bone formation was induced within 3 weeks. On the other hand, in the PLG reservoir with BMP scarcely any bone formation could be observed. The results suggest that the carrier system is most important for the development of BMP-induced bone formation and the PLGiPEG reservoir system is available for BMP delivery.

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