Ectopic Expression of B7-1 (CD80) on T Lymphocytes in AutoimmunelprandgldMice
β Scribed by Jory P Weintraub; Philip L Cohen
- Book ID
- 115593661
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 133 KB
- Volume
- 91
- Category
- Article
- ISSN
- 1090-2341
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Costimulation mediated by costimulatory molecules, such as B7-1 and B7-2, which are ligands for the CD28/cytolytic T lymphocyte associated antigen (CTLA)-4 counter-receptor, plays an important role in the induction of T cell-mediated antitumor immunity. We investigated the expressions of B7-1, B7-2,
87-I (CD80) provides co-stimulation for T-cell activation by interacting with CD28 or CTLA4. Here we demonstrate the expression of 87-I in freshly isolated and cultured lymphocytes from renal-cell carcinoma. In fresh preparations of lymphocytes infiltrating renal-cell-carcinoma tissue, B7-I mRNA cou