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Echo-planar imaging of diffusion and perfusion

✍ Scribed by Robert Turner; Denis Le Bihan; A. Scott Chesnicks

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
463 KB
Volume
19
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Use of the Stejskal‐Tanner sequence for performing diffusion images in the human brain tends to be complicated by the presence of artifacts caused by voluntary or involuntary, sometimes pulsatile, motion. We describe the implementation of the technique of echo‐planar diffusion imaging, which avoids these artifacts and allows reproducible quantitative values of the diffusion coefficient to be measured in vivo. The effects of perfusion are easily visible in a phantom containing a gel. The results for human brain show a significant “perfusion fraction” in grey matter, consistent with an extracellular, possibly microvascular, volume of about 10%. © 1991 Academic Press, Inc.

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