Early virological suppression is associated with good maintained response to adefovir dipivoxil in lamivudine resistant chronic hepatitis B
β Scribed by H. L.-Y. CHAN; V. W.-S. WONG; C.-H. TSE; A. M.-L. CHIM; H.-Y. CHAN; G. L.-H. WONG; J. J.-Y. SUNG
- Book ID
- 108604904
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 466 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0269-2813
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## Abstract Factors influencing the therapeutic efficacy of adefovir dipivoxil added to continuing lamivudine have not been elucidated in lamivudineβresistant patients with type B chronic hepatitis. The viral mutations influencing the efficacy of treatment with adefovir dipivoxil were investigated
## Abstract The aims of this study were to assess the longβterm efficacy of lamivudine (LAM) plus adefovir dipivoxil (ADV) combination therapy in patients with chronic hepatitis B resistant to LAM, to identify predictive factors of complete viral response (HBVβDNA <2.6βlogβcopies/ml at 12 months of