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Early subcortical amyloid deposition in familial Alzheimer's disease is accompanied by changes in tissue volume and diffusivity

✍ Scribed by Natalie S. Ryan; Aren Okello; William D. Knight; Manja Lehmann; Ian Malone; Matthew J. Clarkson; Jonathan Bartlett; Gerard R. Ridgway; Laura Mancini; John Thornton; Sebastian Ourselin; David J. Brooks; Martin N. Rossor; Nick C. Fox


Book ID
118466211
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
473 KB
Volume
6
Category
Article
ISSN
1552-5260

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To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid beta-protein precursor (APP) mutations linked to familial Alzheimer's disease (FAD) increase the extracellular concentration of amyloid beta-protein (A beta) ending at A beta 42(43) in vivo, we performed a blinded comparison