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Amyloid Angiopathy and Variability in Amyloid β Deposition Is Determined by Mutation Position in Presenilin-1-Linked Alzheimer’s Disease

✍ Scribed by David M.A. Mann; Stuart M. Pickering-Brown; Ayano Takeuchi; Takeshi Iwatsubo

Book ID
117022324
Publisher
American Society for Investigative Pathology
Year
2001
Tongue
English
Weight
860 KB
Volume
158
Category
Article
ISSN
0002-9440

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To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid beta-protein precursor (APP) mutations linked to familial Alzheimer's disease (FAD) increase the extracellular concentration of amyloid beta-protein (A beta) ending at A beta 42(43) in vivo, we performed a blinded comparison