Early stages of p53-induced apoptosis are reversible
β Scribed by Geske, F J; Lieberman, R; Strange, R; Gerschenson, L E
- Book ID
- 110016157
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 613 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1350-9047
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## Summary Chromatin condensation and nDNA fragmentation, indicators of apoptosis in mammalian cells, occur in plant cells during senescence and following induction by chemical agents. In __Nicotiana plumbaginifolia__ cells, camptothecin, okadaic acid, salicylic acid, hydrogen peroxide, and the cal
Activation of the tumor suppressor protein p53 can lead to arrest in both G 1 and G 2 stages of the cell cycle and, in some cells, to apoptotic cell death. In this study, we showed that the p53 response to a chemotherapeutic drug, actinomycin D, was reversible in both normal and tumor cells, even wh