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Early Expression of a T-Cell Receptor β -Chain Transgene Suppresses Rearrangement of the Vγ 4Gene Segment

✍ Scribed by Harald Von Boehmer, Marc Bonneville, Isao Ishida, Stefan Ryser, Gloria Lincoln, Richard T. Smith, Hiroyuki Kishi, Bernadette Scott, Pawel Kisielow and Susumu Tonegawa


Book ID
123636219
Publisher
National Academy of Sciences
Year
1988
Tongue
English
Weight
718 KB
Volume
85
Category
Article
ISSN
0027-8424

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We have studied the diversity of the expressed human T-cell receptor (TCR) beta-chain repertoire by analysis of mRNA from unstimulated peripheral blood T-cells. The anchored-polymerase chain reaction (PCR) was used to isolate TCRB transcripts. Of 20 full or near full-length functional transcripts se