Early Detection of Viral Resistance by Determination of Hepatitis B Virus Polymerase Mutations in Patients Treated by Lamivudine for Chronic Hepatitis B
✍ Scribed by Si Nafa; Si Ahmed; David Tavan; Christian Pichoud; Françoise Berby; Lieven Stuyver; Mark Johnson; Philippe Merle; Hassane Abidi; Christian Trépo; Fabien Zoulim
- Book ID
- 111721209
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 423 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Lamivudine is effective in suppressing replication of hepatitis B virus (HBV). However, the emergence of HBV variants resistant to lamivudine is a concern. Lamivudine resistance has been attributed mainly to a substitution of isoleucine or valine for methionine at residue 550 (M550I or M550V) in the
## Abstract Hepatitis B virus (HBV) DNA was assayed using the polymerase chain reaction in serum samples of 116 hepatitis B surface antigen (HBsAg) carriers, including 30 positive for hepatitis B e antigen (HBeAg) and 86 negative for HBeAg. In the HBeAg‐positive group, all were positive for HBV DNA