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Early decrease of mitochondrial DNA repair enzymes in spinal motor neurons of presymptomatic transgenic mice carrying a mutant SOD1 gene

โœ Scribed by Tetsuro Murakami; Makiko Nagai; Kazunori Miyazaki; Nobutoshi Morimoto; Yasuyuki Ohta; Tomoko Kurata; Yasushi Takehisa; Tatsushi Kamiya; Koji Abe


Book ID
113502654
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
459 KB
Volume
1150
Category
Article
ISSN
0006-8993

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## Abstract Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disease caused by the selective death of motor neurons. Between 5% and 10% of ALS patients have a genetically inherited form of the disease known as familial ALS (FALS), and approximately 20% of FALS patients have mutations