𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Early and late B-cell development in the mouse

✍ Scribed by Klaus Rajewsky

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
846 KB
Volume
4
Category
Article
ISSN
0952-7915

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✦ Synopsis

A common principle in B-cell development is the stringent selection of cells expressing appropriate antibody V regions as surface receptors. Cells failing to do so appear destined to rapid death. These life-death decisions are mediated by signals whose nature is not yet understood but whose generation involves immunoglobulin receptor complexes on B cells and B-cell progenitors.

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