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Trophoblast giant cells express NF-?B2 during early mouse development

✍ Scribed by Muggia, Anna ;Teesalu, Tambet ;Neri, Antonino ;Blasi, Francesco ;Talarico, Daniela

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
617 KB
Volume
25
Category
Article
ISSN
0192-253X

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✦ Synopsis

To investigate whether transcription factors of the NF-B family could play a role in early mammalian development, we have analyzed the expression of nfkb1, nfkb2, c-Rel, RelA, RelB, and bcl-3 from 6.5-to 10.5-day mouse embryo implantation sites. Our study shows that nfkb2 mRNA and protein are specifically localized in trophoblast giant cells throughout the stages analyzed. Trophoblast giant cells obtained upon in vitro cultures of 7.5-day ectoplacental cones display NF-B DNA-binding activity that is supershifted by the anti-NF-B2 antibody. Trophoblast giant cells are embryoderived cells that form an interface between embryonic and maternal tissues during early mouse development; they are involved in decidual remodeling and expansion of the embryonic cavity, placenta formation, and possibly avoidance of maternal immune response to the embryo. Our study suggests that NF-B2 could play a role in the modulation of genes expressed in trophoblast giant cells during the course of early embryogenesis, and therefore be relevant for tissue remodeling and

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