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E2F1 in gliomas: A paradigm of oncogene addiction

โœ Scribed by Marta M. Alonso; Ramon Alemany; Juan Fueyo; Candelaria Gomez-Manzano

Book ID
116334680
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
193 KB
Volume
263
Category
Article
ISSN
0304-3835

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Cancer cells often contain mutations that lead to the loss of retinoblastoma tumor suppressor (Rb) function and the activation of E2F-dependent transcription. As a result, proliferation is deregulated, and sensitivity to apoptotic stimuli is increased. In cell culture studies, the transcription fact