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E-cadherin expression is silenced by DNA methylation in cervical cancer cell lines and tumours

โœ Scribed by C.-L Chen; S.S Liu; S.-M Ip; L.C Wong; H.Y.S Ngan; T.Y Ng

Book ID
117659021
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
273 KB
Volume
39
Category
Article
ISSN
0959-8049

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Reduction of E-cadherin strongly relates to invasiveness and metastasis in vitro. To clarify CpG methylation around the promoter region of the E-cadherin gene in oral squamous cell carcinoma (SCC), we examined the DNA samples of various human SCC cell lines and primary oral SCC tissues by methylatio