We analyzed a set of 103 non-small cell lung carcinomas (NSCLCs) for caspase-3, -6 and -8 expression and apoptosis. Additionally, the expression of bcl-2, bax and p53 were studied. Caspase-3 positivity appeared as diffuse, cytoplasmic staining and was restricted to the tumor area. In contrast, the i
✦ LIBER ✦
Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation
✍ Scribed by Hopkins-Donaldson, S; Ziegler, A; Kurtz, S; Bigosch, C; Kandioler, D; Ludwig, C; Zangemeister-Wittke, U; Stahel, R
- Book ID
- 110016487
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 336 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1350-9047
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## BACKGROUND. Antagonists of bombesin/gastrin-releasing peptide (BN/GRP) have been developed to block the autocrine stimulatory effect of BN/GRP on tumors such as small cell lung carcinoma (SCLC). Although several studies have addressed the intracellular events that follow the formation of the re