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Dysregulation of the BMP-4 Signaling Pathway in Fibrodysplasia Ossificans Progressiva

✍ Scribed by FREDERICK S. KAPLAN; JENNIFER FIORI; LOURDES SERRANO DE LA PEÑA; JAIMO AHN; PAUL C. BILLINGS; EILEEN M. SHORE


Book ID
111479327
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
92 KB
Volume
1068
Category
Article
ISSN
0890-6564

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## Abstract Cell surface heparan sulfate proteoglycans (HSPGs) play important roles in morphogen gradient formation and cell signaling. Bone morphogenetic protein (BMP) signaling is dysregulated in fibrodysplasia ossificans progressiva (FOP), a disabling disorder of progressive heterotopic bone for