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Dysmyelinating and demyelinating Charcot–Marie–Tooth disease associated with two myelin protein zero gene mutations

✍ Scribed by Hanna Drac; Dagmara Kabzińska; Izabela Moszyńska; Halina Strugalska-Cynowska; Irena Hausmanowa-Petrusewicz; Andrzej Kochański


Book ID
107700424
Publisher
Springer-Verlag
Year
2010
Tongue
English
Weight
344 KB
Volume
52
Category
Article
ISSN
1234-1983

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The myelin protein zero gene (MPZ) maps to chromosome lq22-23 and encodes the most abundant peripheral nerve myelin protein. The Po protein functions as a homophilic adhesion molecule in myelin compaction. Mutations in the MPZ gene are associated with the demyelinating peripheral neuropathies Charco