Dyslipoproteinemia in pediatric systemic lupus erythematosus

✍ Scribed by Norman T. Ilowite; Paul Samuel; Ellen Ginzler; Marc S. Jacobson

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 523 KB
• Volume: 31
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780310706

✦ Synopsis

Patients with systemic lupus erythematosus are at increased risk for premature atherosclerosis. We examined one possible etiologic factor, dyslipoproteinemia, both before and after corticosteroid therapy. We identified 2 distinct patterns of dyslipoproteinemia. One is attributable to active disease; the other is attributable, in part, to corticosteroid therapy. The dyslipoproteinemia of active disease consists of depressed high density lipoprotein cholesterol and apoprotein A-I with elevated very low density lipoprotein cholesterol and triglyceride, while the dyslipoproteinemia after corticosteroid therapy consists of increased total cholesterol, very low density lipoprotein cholesterol, and triglyceride. The possible pathophysiologic mechanisms responsible for these patterns, as well as the possible roles in premature

From the State Universities of New York at Stony Brook and Brooklyn,