๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Dysfunction of Ib (Autogenic) spinal inhibition in patients with progressive supranuclear palsy

โœ Scribed by Dr. Edward J. Fine; Mark Hallett; Irene Litvan; Nancy Tresser; David Katz

Book ID
102949267
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
850 KB
Volume
13
Category
Article
ISSN
0885-3185

No coin nor oath required. For personal study only.

โœฆ Synopsis

Abstract

We compared the activity of Ib spinal interneurons in five patients with progressive supranuclear palsy (PSP) with six ageโ€matched control subjects. Stimulation of the medial gastrocnemius nerve at motor threshold intensity activated Ib afferents that in turn inhibit H reflexes from the soleus muscle. Maximum inhibition occurred at interstimulus intervals of 6 and 8 ms for both control subjects and PSP patients and was significantly greater in the PSP patients. Increased Ib activity of PSP patients may be caused by loss of inhibition of Ib interneurons through degeneration of the medullary reticulospinal pathway. The corticospinal pathways, unopposed by the medullary reticulospinal tract, may excessively activate Ib internurons.

๐Ÿ“œ SIMILAR VOLUMES

Autonomic dysfunction in patients with p
Autonomic dysfunction in patients with progressive supranuclear palsy
โœ Claudia Schmidt; Birgit Herting; Silke Prieur; Susann Junghanns; Katherine Schwe ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 228 KB

## Abstract The most important features that characterize and differentiate progressive supranuclear palsy (PSP) from other parkinsonian syndromes are postural instability, supranuclear gaze palsy, pseudobulbar palsy, and cognitive disturbances. Although it has been reported that significant autono

Health-related quality of life in patien
Health-related quality of life in patients with progressive supranuclear palsy
โœ Anette Schrag; Caroline Selai; Jennifer Davis; Andrew J. Lees; Marjan Jahanshahi ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 65 KB

## Abstract We assessed healthโ€related quality of life (QoL) of patients with progressive supranuclear palsy (PSP), identified the most important QoL issues in patients with this disorder, and assessed the usefulness of existing QoL measures in patients with PSP. Twentyโ€seven patients in all stages

Mitochondrial impairment in the cerebell
Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy
โœ Larry C.H. Park; David S. Albers; Hui Xu; J. Gordon Lindsay; M. Flint Beal; Gary ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 134 KB

## Abstract Abnormalities in energy metabolism and oxidative stress accompany many neurodegenerative diseases, including progressive supranuclear palsy (PSP). Previously, we showed decreased activities of a mitochondrial enzyme complex, ฮฑโ€ketoglutarate dehydrogenase complex (KGDHC), and marked incr

Nigrostriatal upregulation of 5-HT2A rec
Nigrostriatal upregulation of 5-HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy
โœ Maria Stamelou; Andreas Matusch; David Elmenhorst; Renรฉ Hurlemann; Karla M. Egge ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 240 KB

## Abstract A dysfunction of multiple neurotransmitter systems is assumed as a neurochemical basis of the akineticโ€rigid syndrome of progressive supranuclear palsy (PSP). In vitro studies have produced conflicting results on the serotoninergic system in PSP. We, therefore, studied the binding poten