✦ LIBER ✦

Autonomic dysfunction in patients with progressive supranuclear palsy

✍ Scribed by Claudia Schmidt; Birgit Herting; Silke Prieur; Susann Junghanns; Katherine Schweitzer; Heinz Reichmann; Daniela Berg; Tjalf Ziemssen

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 228 KB
Volume: 23
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.22289

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The most important features that characterize and differentiate progressive supranuclear palsy (PSP) from other parkinsonian syndromes are postural instability, supranuclear gaze palsy, pseudobulbar palsy, and cognitive disturbances. Although it has been reported that significant autonomic dysfunction is an exclusionary feature for PSP diagnosis, we could demonstrate in this study using semiquantitative clinical interview and cardiovascular testing that both PSP and idiopathic Parkinson's disease (PD) patients can present with significant autonomic dysfunction. The parasympathetic cardiovascular system seems to be involved to a similar extent in PD and PSP patients, whereas sympathetic cardiovascular dysfunction is more frequent and severe in PD patients, but can also be found in PSP patients. Our findings have a profound implication on the diagnosis and treatment of PSP patients. © 2008 Movement Disorder Society

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