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Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis

✍ Scribed by Rachael L. Neve; Donna L. McPhie


Book ID
116270534
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
313 KB
Volume
1772
Category
Article
ISSN
0925-4439

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Previous reports have shown that exposure of vascular endothelial and smooth muscle cells to exogenous amyloid beta (A␀) peptide results in cell damage and toxicity via oxidative injury. In this study we demonstrate that overexpression of the amyloid precursor protein (APP) is toxic to bovine aortic