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DyNAs: Constitutional Dynamic Nucleic Acid Analogues

✍ Scribed by Nampally Sreenivasachary; David T. Hickman; Dominique Sarazin; Jean-Marie Lehn

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
283 KB
Volume
12
Category
Article
ISSN
0947-6539

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✦ Synopsis

Abstract

Dynamic cationic polymers were generated in aqueous media from functionally complementary monomers bearing nucleobase groups. ^1^H NMR spectroscopy was used to follow the polycondensation reaction of the nucleobase‐appended dihydrazides 1 and 2 with the dialdehydes B and C. The reversibility of these polymers was established by proton NMR spectroscopy through exchange of the dihydrazide 2 with polymer 1 B. The polymers 1 B, 2 B, 1 C, and 2 C represent dynamic biopolymers of nucleic acid type, DyNAs. Electrostatic interaction of these polymers with polyanionic entities, such as polyphosphates, polynucleotides, and polyaspartic acid, was shown to take place. It induces a change in size of the dynamic polymer, as it responds by an increase in degree of polymerization to an increase of the overall anionic charge introduced, that is, to the total electrostatic interaction.

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