1-Thiapyrimidines sulphur analogues of nucleic acid bases
โ Scribed by R.N. Warrener; E.N. Cain
- Publisher
- Elsevier Science
- Year
- 1966
- Tongue
- French
- Weight
- 215 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
Analogues
of nucleic acid bases have been shown to be incorporated ' into the R N A . . . or D.N.A. of certain viruses, micro organisms and mammalian cells. This results in the formation of "deformed" nucleic acids, which may subsequently interfere with growth and reproductive processes. These
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## Abstract Atomistic simulations of nucleic acids are prohibitively expensive and, consequently, reduced models of these compounds are of great interest in the field. In this work, we propose a physicsโbased coarseโgrained model of nucleicโacid bases in which each base is represented by several (3