Dynamics of Cholinergic Function

✍ Scribed by L. L. Butcher, N. J. Woolf (auth.), Israel Hanin Ph.D. (eds.)

• Publisher: Springer US
• Year: 1986
• Tongue: English
• Leaves: 1241
• Series: Advances in Behavioral Biology 30
• Category: Library

✦ Table of Contents

Front Matter....Pages i-xviii
Cholinergic Systems in the Central Nervous System: Retrospection, Anatomic Distribution, and Functions....Pages 1-10
Cholinergic Neurons and Cholinergic Projections in the Mammalian CNS....Pages 11-21
Cortical Cholinergic Innervation: Distribution and Source in Monkeys....Pages 23-30
Identification of Putative M 1 Muscarinic Receptors Using [ 3 H]Pirenzepine: Characterization of Binding and Autoradiographic Localization in Human Stellate Ganglia....Pages 31-41
Neurotransmitters That Act on Cholinergic Magnocellular Forebrain Nuclei Influence Cortical Acetylcholine Output....Pages 43-50
Biochemistry and Immunocytochemistry of Choline Acetyltransferase....Pages 51-63
Autoradiographic Localization of Subtypes of Muscarinic Agonist and Antagonist Binding Sites: Alterations Following CNS Lesions....Pages 65-78
Immunocytochemical Evidence for the Intra-Axonal Transport of nAChR-Like Material in Motor Neurons....Pages 79-91
Lateralization of Cholinergic and Energy Metabolism Related Enzymes in Human Temporal Cortex....Pages 93-98
Immunological Approach to Cholinergic Transmission: Production of Monoclonal Antibodies Against Presynaptic Membranes Isolated from the Electric Organ of Torpedo Marmorata ....Pages 99-110
Reduced Acetylcholine Synthesis in Alzheimer’s Disease is a Clinically Relevant Change....Pages 111-121
Cortical Cholinergic Hypofunction and Behavioral Impairment Produced by Basal Forebrain Lesions in the Rat....Pages 123-131
Clinical Studies of the Cholinergic Deficit in Alzheimer’s Disease....Pages 133-151
Protection and Therapeutic Effect of CDP Choline in Hypocapnic Neurons in Culture....Pages 153-163
The Aging of Cholinergic Synapses: Ontogenesis of Cholinergic Receptors....Pages 165-175
Aging of Cholinergic Synapses: Fiction or Reality?....Pages 177-190
Interactions of Calcium Homeostasis, Acetylcholine Metabolism, Behavior and 3,4-Diaminopyridine during Aging....Pages 191-204
Cholinergic Dysfunction and Memory; Implications for the Development of Animal Models of Aging and Dementia....Pages 205-213
Relationships between Choline Acetyltransferase and Muscarinic Binding in Aging Rodent Brain and in Alzheimer’s Disease....Pages 215-224
Cholinergic Hypofunction and Dementia: Relation of Neuronal Loss in Different Parts of the Nucleus Basalis to Cortical Neuropathological Changes....Pages 225-234
Basal Forebrain Cholinergic Systems in Primate Brain: Anatomical Organization and Role in the Pathology of Aging and Dementia....Pages 235-242
Cell Counts in the Nucleus Basalis of Meynert and the Supraoptic Nucleus in Alzheimer-Diseased Brains....Pages 243-250
Sympathetic Ingrowth: A Result of Cholinergic Nerve Injury in the Adult Mammalian Brain....Pages 251-259
Determinants of Acetylcholine Levels in Aged Rats....Pages 261-271
Elevated Red Cell to Plasma Choline Ratios in Alzheimer’s Disease....Pages 273-282
Plasma and Red Blood Cell Choline in Aging: Rats, Monkeys and Man....Pages 283-290
Human Red Blood Cell Choline in Aging and Senile Dementia: Effects of Precursor Therapy....Pages 291-301
The Use of Positron Emission Tomography for the Evaluation of Choline Metabolism in the Brain of the Rhesus Monkey....Pages 303-311
Cholinergic Mechanisms in Spinal Cord and Muscle....Pages 313-323
Central Acetylcholine and Stress Induced Cardiovascular, Neuroendocrine and Behavioral Changes: Effects of Physostigmine and Neostigmine....Pages 325-334
Muscarinic Supersensitivity of Anterior Pituitary Acth and β -Endorphin Release in Major Depressive Illness....Pages 335-341
Cholinergic Receptor Binding in the Frontal Cortex of Suicide Victims....Pages 343-349
Membrane Transport of Choline by the Human Erythrocyte: Relationship to Intracellular Choline Content, and Effect of Treatment with Lithium....Pages 351-364
Studies on the Synaptic Function in Muscle after Nerve Crush in Normal and Diabetic Rats....Pages 365-374
Cholinergic Rem Sleep Induction Response as a Marker of Endogenous Depression....Pages 375-383
Stereoselectivity of Some Muscarinic and Antimuscarinic Agents Related to Oxotremorine....Pages 385-393
Affinity and Efficacy of Oxotremorine Analogs at Ileal Muscarinic Receptors....Pages 395-404
In Vivo and in Vitro Studies on a Muscarinic Presynaptic Antagonist and Postsynaptic Agonist: BM-5....Pages 405-413
Interactions of Alaproclate, a Selective 5HT-Uptake Blocker, with Muscarinic Receptors: In Vivo and In Vitro Studies....Pages 415-422
Presynaptic Muscarinic Receptors: Change of Sensitivity During Long-Term Drug Treatment....Pages 423-428
Characterization of [ 3 H]-Nicotine Binding in Rodent Brain and Comparison with the Binding of Other Labelled Nicotinic Ligands....Pages 429-437
The Cholinergic Ligand Binding Material of Axonal Membranes....Pages 439-446
Do Motor Neurons Contain Functional Prejunctional Cholinoceptors?....Pages 447-457
Pharmacological Characterization of Axonally Transported [ 125 I]- α -Bungarotoxin Binding Sites in Rat Sciatic Nerve....Pages 459-466
Nicotinic Cholinergic Receptors Labeled with [ 3 H]Acetylcholine in Brain: Characterization, Localization and In Vivo Regulation....Pages 467-479
Resting Release of Acetylcholine at the Motor Endplate....Pages 481-487
Evoked Release of Acetylcholine at the Motor Endplate....Pages 489-497
Depolarization Induced Hydrolysis of Cytoplasmic ACh in Mouse Brain....Pages 499-507
Separation of Recycling and Reserve Synaptic Vesicles from Cholinergic Nerve Terminals of the Myenteric Plexus of Guinea-Pig Ileum....Pages 509-517
Biochemical Implications of the Synaptic Vesicle Organization in Quick Frozen Electric Organ Nerve Terminals....Pages 519-527
Presynaptic Changes Accompanying Transmission of a Single Nerve Impulse: An Interdisciplinary Approach Using Rapid Freezing....Pages 529-538
Tentative Identification of the Choline Transporter in Cholinergic Presynaptic Plasma Membrane Preparations from Torpedo Electric Organ....Pages 539-550
A Reconstituted Presynaptic Membrane Equipped with Protein Structures Which Permit the Calcium Dependent Release of Acetylcholine....Pages 551-564
Storage and Secretion of Acetylcholine and Dopamine by PC12 Cells....Pages 565-574
Effects of Exogenous Choline on Acetylcholine and Choline Contents and Release in Striatal Slices....Pages 575-581
Acetylcholine and Choline Contents of Rat Skeletal Muscle Determined by a Radioenzymatic Microassay: Effects of Drugs....Pages 583-592
Pre- and Postsynaptic Effects of Muscarinic Antagonists in the Isolated Guinea Pig Ileum....Pages 593-598
Presynaptic Modulation of Acetylcholine Release....Pages 599-606
Effect of Diisopropylfluorophosphate on Synaptic Transmission and Acetylcholine Sensitivity in Neuroblastoma-Myotube Co-Culture....Pages 607-619
Acetylcholine Release from Rat Diaphragm: A Search for Release Regulatory Mechanisms....Pages 621-626
Distribution of Presynaptic Receptors Modulating Acetylcholine Release....Pages 627-632
Muscarinic Receptor Activation Increases Efflux of Choline from Isolated Heart and Rat Cortex in Vivo . Interactions with Forskolin and IBMX....Pages 633-641
Long Term Potentiation of Cholinergic Transmission in the Sympathetic Ganglion....Pages 643-651
Control of the Release of [ 3 H]-Acetylcholine from Rat Hippocampal Slices by Aminopyridines and Phencyclidine....Pages 653-660
A Comparison between Endogenous Acetylcholinerelease and [ 3 H] Choline Outflow from Guinea-Pig Brain Slices....Pages 661-666
Relationship between Calcium Entry and ACh Release in K + -Stimulated Rat Brain Synaptosomes....Pages 667-675
Activation and Inhibition of the Nicotinic Receptor: Actions of Physostigmine, Pyridostigmine and Meproadifen....Pages 677-695
Molecular Relationship between Acetylcholinesterase and Acetylcholine Receptors....Pages 697-704
Acetylcholinesterase and the Maintenance of Neuromuscular Structure and Function....Pages 705-718
Striatal Dopamine- γ -Aminobutyric Acid-Acetylcholine Interaction in Organophosphate-Induced Neurotoxicity....Pages 719-726
Polymorphism of Cholinesterase: Possible Insertion of the Various Molecular Forms in Cellular Structures....Pages 727-732
An Endogenous Neurotrophic Factor for the Maintenance of Acetylcholinesterase and Butyrylcholinesterase in the Preganglionically Denervated Superior Cervical Ganglion of the Cat....Pages 733-741
Pharmacokinetics of [ 14 C]-Sarin and Its Changes by Obidoxime and Pralidoxime....Pages 743-755
Succinylcholine — A Method of Determination. Distribution and Elimination....Pages 757-766
Cholinergic Effects of HI-6 in Soman Poisoning....Pages 767-779
Acetylcholine Turnover in Mouse Brain: Influence of Cholinesterase Inhibitors....Pages 781-790
Central Versus Peripheral Antagonism of Cholinesterase Inhibitor Induced Lethality....Pages 791-798
Structural Gene Mutations Affecting Acetylcholinesterase and Choline Acetyltransferase Perturb Behavior and Development in a Simple Invertebrate....Pages 799-816
Choline Fluxes to and from the Rat Cerebral Cortex Studied with the “Cup Technique” in Vivo ....Pages 817-825
Biochemical Effects of Lecithin Administration....Pages 827-835
Factors Which Influence the Availability of Choline to Brain....Pages 837-849
The Utilization of Supplemental Choline by Brain....Pages 851-858
Effects of the Combined Treatment of Rats with Fluphenazine and Choline or Lecithin on the Striatal Cholinergic and Dopaminergic System....Pages 859-867
Mechanisms of Acetylcholine Synthesis: Coupling with Choline Transport....Pages 869-878
Target Tissue Influences on Cholinergic Development of Parasympathetic Motor Neurons....Pages 879-890
Inhibition of Acetylcholine Synthesis in Vitro ....Pages 891-906
The Role of Glial Cells in Neuronal Acetylcholine Synthesis....Pages 907-913
The Efflux of Choline from Nerve Cells: Mediation by Ionic Gradients and Functional Exchange of Choline from Glia to Neurons....Pages 915-922
Choline Uptake in the Hippocampus: Inhibition of Septal-Hippocampal Cholinergic Neurons by Intraventricular Barbiturates....Pages 923-932
Studies on a cAMP-Dependent Protein Kinase Obtained from Nicotinic Receptor-Bearing Microsacs....Pages 933-937
Differential Effects of Carbachol and Oxotremorine on Muscarinic Receptors, Cyclic Amp Formation, and Phosphoinositide Turnover in Chick Heart Cells....Pages 939-946
Polyphosphoinositide and Phosphoprotein Responses to Muscarinic Receptor Activation in Bovine Adrenal Medulla....Pages 947-951
GABA A VS. GABA B Modulation of Septal-Hippocampal Interconnections....Pages 953-961
Septal Gabaergic Neurons: Localization and Possible Involvement in the Septal-Hippocampal Feedback Loop....Pages 963-971
Regulation of Drugs Affecting Striatal Cholinergic Activity by Corticostriatal Projections....Pages 973-980
Excitatory Amino Acid Influence on Striatal Cholinergic Transmission....Pages 981-990
Contribution of the Dorsal Noradrenergic Bundle to the Effect of Amphetamine on Acetylcholine Turnover....Pages 991-998
Substantia Innominata — Cortical Cholinergic Pathway: Regulatory Afferents....Pages 999-1006
Enkephalinergic Modulation of Cholinergic Transmission in Parasympathetic Ganglia of the Cat Urinary Bladder....Pages 1007-1017
Vasoactive Intestinal Polypeptide-Muscarinic Cholinergic Interactions....Pages 1019-1025
Serotonin and a Role in the Modulation of Cholinergic Transmission in the Mammalian Prevertebral Ganglia....Pages 1027-1037
Cholinergic and Peptidergic Regulation of Ganglionic Tyrosine Hydroxylase Activity....Pages 1039-1045
Regulation of Acetylcholine Release From Rodent Cerebrum by Presynaptic Receptors, Methionine Enkephalin and Substance P....Pages 1047-1056
Selective Facilitatory Effects of Vasoactive Intestinal Polypeptide on Muscarinic Mechanisms in Sympathetic and Parasympathetic Ganglia of the Cat....Pages 1057-1066
Interaction of Cyclic Amp with Muscarinic Autoinhibition of [ 3 H]-Acetylcholine Secretion in Guinea-Pig Ileum Myenteric Plexus....Pages 1067-1069
Parasympathetic Innervation of the Heart: Acetylcholine Turnover in Vivo ....Pages 1071-1080
Tendency for Repetitive Vagal Activity to Synchronize Cardiac Pacemaker Cells....Pages 1081-1090
Transient Inotropic and Dromotropic Responses to Brief Vagal Stimuli....Pages 1091-1100
Brain Acetylcholine in Hypertension and Behavior: Studies Using N-(4-Diethylamino-2-Butynyl)-Succinimide....Pages 1101-1108
Inhibition of Brain Acetylcholine Biosynthesis by Clonidine and Methyldopa: Relevance to Hypertensive Disease....Pages 1109-1118
Acetylcholine — Prostanoid Interaction in the Pulmonary Circulation....Pages 1119-1126
Long-Term Effects of AF64A on Learning and Memory Processes in the Rat....Pages 1127-1136
Biochemical and Behavioral Effects of Ethylcholine Mustard Aziridinium Ion....Pages 1137-1143
Histochemical and Biochemical Effects of the Injection of AF64A into The Nucleus Basalis of Meynert:Relevance to Animal Models of Senile Dementia of the Alzheimer Type....Pages 1145-1150
Neurotoxic Effects of Nitrogen Mustard Analogues of Choline....Pages 1151-1160
Synthesis, Storage and Release of Choline Analog Esters....Pages 1161-1168
A New Pharmacological Tool to Study Acetylcholine Storage in Nerve Terminals....Pages 1169-1176
Alkylating Derivatives of Oxotremorine Have Irreversible Actions on Muscarinic Receptors....Pages 1177-1185
Action of Phospholipase Neurotoxins on Torpedo Synaptosomes: Changes in Membrane Potential and Phosphoglyceride Composition....Pages 1187-1201
Studies of Two Novel Presynaptic Toxins....Pages 1203-1213
Conference on Dynamics of Cholinergic Function: Overview and Comments....Pages 1215-1261
Back Matter....Pages 1263-1273

✦ Subjects

Vibration, Dynamical Systems, Control