Cholinergic Function and Dysfunction

✍ Scribed by A. Claudio Cuello (Eds.)

• Publisher: Academic Press, Elsevier
• Year: 1993
• Leaves: 446
• Series: Progress in Brain Research 98
• Category: Library

✦ Table of Contents

Content:
Editorial Page
Page iii

Copyright Page
Page iv

List of Contributors
Pages v-ix

Preface
Pages xi-xii
A. Claudio Cuello

In memoriam Shosaku Numa
Pages xiii-xiv
Herbert Ladinsky

In memoriam Frank Campbell MacIntosh
Pages xv-xvi
Brian Collier

Chapter 1: Cholinergic neurons identified by in situ hybridization histochemistry Original Research Article
Pages 1-8
Larry L. Butcher, Justin D. Oh, Nancy J. Woolf

Chapter 2: Ascending cholinergic pathways: functional organization and implications for disease models Original Research Article
Pages 9-30
Bruce H. Wainer, Teresa L. Steininger, John D. Roback, Melanie A. Burke-Watson, Elliott J. Mufson, Jeffrey Kordower

Chapter 3: Catecholaminergic-cholinergic interaction in the basal forebrain Original Research Article
Pages 31-49
L. Záborszky, W.E. Cullinan, V.N. Luine

Chapter 4: Cholinergic systems: human diseases, animal models, and prospects for therapy Original Research Article
Pages 51-60
Donald L. Price, Vassilis E. Koliatsos, Richard C. Clatterbuck

Chapter 5: The organization of central cholinergic systems and their functional importance in sleep-waking states Original Research Article
Pages 61-71
Barbara E. Jones

Chapter 6: CNS distribution of cholinergic receptors - some questions from a clinical neuroscientist Original Research Article
Pages 73-75
Sten-Magnus Aquilonius

Chapter 7: Nicotinic receptors in mammalian brain: localization and relation to cholinergic innervation Original Research Article
Pages 77-83
Paul B.S. Clarke

Chapter 8: Autoradiographic distribution of putative muscarinic receptor sub-types in mammalian brain Original Research Article
Pages 85-93
Rémi Quirion, Isabelle Aubert, Dalia M. Araujo, Ali Hersi, Pierrette Gaudreau

Chapter 9: Advances and limitations of the molecular neuroanatomy of cholinergic receptors: the example of multiple muscarinic receptors Original Research Article
Pages 95-101
M.T. Vilaró, G. Mengod, J.M. Palacios

Chapter 10: Acetylcholine receptors: drugs and molecular genetics Original Research Article
Pages 103-111
Herbert Ladinsky

Chapter 11: Functional diversity of neuronal nicotinic acetylcholine receptors Original Research Article
Pages 113-120
Jim Patrick, Philippe Séquéla, Steven Vernino, Mariano Amador, Chuck Luetje, John A. Dani

Chapter 12: Muscarinic acetylcholine receptor subtypes: localization and structure/function Original Research Article
Pages 121-127
Mark R. Brann, John Ellis, Hans Jørgensen, David Hill-Eubanks, S.V. Penelope Jones

Chapter 13: Evolution and acetylcholine receptors Original Research Article
Pages 129-131
A.S.V. Burgen

Chapter 14: Molecular biology of cholinesterases: a background and an introduction Original Research Article
Pages 133-138
E. Heilbronn

Chapter 15: Structure and functions of acetylcholinesterase and butyrylcholinesterase Original Research Article
Pages 139-146
Jean Massoulié, Joel Sussman, Suzanne Bon, Israel Silman

Chapter 16: Promoter elements and alternative splicing in the human ACHE gene Original Research Article
Pages 147-153
Revital Ben Aziz-Aloya, Meira Sternfeld, Hermona Soreq

Chapter 17: The cholinesterases: a discussion of some unanswered questions Original Research Article
Pages 155-159
Victor P. Whittaker

Chapter 18: Regulation of the synthesis of acetylcholine Original Research Article
Pages 161-166
R. Jane Rylett, Bonnie M. Schmidt

Chapter 19: Molecular genetic specification of cholinergic neurons Original Research Article
Pages 167-173
Paul M. Salvaterra, Toshihiro Kitamoto, Kazuo Ikeda

Chapter 20: Acetylcholine transporter — vesamicol receptor pharmacology and structure Original Research Article
Pages 175-181
Stanley M. Parsons, Ben A. Bahr, Gary A. Rogers, Edward D. Clarkson, Krystyna Noremberg, Barry W. Hicks

Chapter 21: Storage and release of acetylcholine in a sympathetic ganglion Original Research Article
Pages 183-189
B. Collier, A. Tandon, M.A.M. Prado, M. Bachoo

Chapter 22: Acetylcholine turnover and release: the influence of energy metabolism and systemic choline availability Original Research Article
Pages 191-195
Oscar U. Scremin, Donald J. Jenden

Chapter 23: Choline, a precursor of acetylcholine and phospholipids in the brain Original Research Article
Pages 197-200
Konrad Löffelholz, Jochen Klein, Andrea Köppen

Chapter 24: D₁ and D₂ dopamine receptors and the regulation of striatal acetylcholine release in vivo Original Research Article
Pages 201-207
S. Consolo, P. Girotti, M. Zambelli, G. Russi, M. Benzi, R. Bertorelli

Chapter 25 The non-quantal release of acetylcholine from motor nerve terminals: comment on its likely size Original Research Article
Pages 209-212
Stanislav Tuček, Vladimír Doležal

Chapter 26: Molecular aspects of acetylcholine release: an overview Original Research Article
Pages 213-218
Georgina Rodríguez de Lores Arnaiz

Chapter 27: Acetylcholine release, from molecules to function Original Research Article
Pages 219-233
Maurice Israël, Yves Dunant

Chapter 28: Molecular approaches to synaptic vesicle exocytosis Original Research Article
Pages 235-240
Thomas C. Südhof, Alexander G. Petrenko, Victor P. Whittaker, Reinhard Jahn

Chapter 29: The neurotrophic hypothesis and the cholinergic basal forebrain projection Original Research Article
Pages 241-249
Carrie A. Lucidi-Phillipi, Fred H. Gage

Chapter 30: Nerve growth factor affects the cholinergic neurochemistry and behavior of aged rats Original Research Article
Pages 251-256
Lawrence R. Williams, R. Jane Rylett, Donald K. Ingram, James A. Joseph, Hylan C. Moises, Andrew H. Tang, Ronald F. Mervis

Chapter 31: Protective effects of nerve growth factor and brain-derived neurotrophic factor on basal forebrain cholinergic neurons in adult rats with partial fimbrial transections Original Research Article
Pages 257-263
Franz Hefti, Beat Knusel, Paul A. Lapchak

Chapter 32: Trophic responses of forebrain cholinergic neurons: a discussion Original Research Article
Pages 265-277
A. Claudio Cuello

Chapter 33: Comments to session on electrophysiological aspects of cholinergic mechanisms Original Research Article
Pages 279-284
Alexander G. Karczmar

Chapter 34: Central cholinergic mechanisms and function Original Research Article
Pages 285-292
K. Krnjević

Chapter 35: Postsynaptic actions of acetylcholine: the coupling of muscarinic receptor subtypes to neuronal ion channels Original Research Article
Pages 293-301
M.P. Caulfield, J. Robbins, H. Higashida, D.A. Brown

Chapter 36: Actions of acetylcholine in the cerebral cortex and thalamus and implications for function Original Research Article
Pages 303-308
David A. McCormick

Chapter 37: The phosphoinositide signalling system. I. Historical background. II. Effects of lithium on the accumulation of second messenger inositol 1,4,5-trisphosphate in brain cortex slices Original Research Article
Pages 309-315
Lowell E. Hokin, John F. Dixon

Chapter 38: Lithium selectively potentiates cholinergic activity in rat brain Original Research Article
Pages 317-322
Richard S. Jope

Chapter 39: Characteristics of the changes in intracellular calcium concentration on the activation of muscarinic receptors in hippocampal neurons Original Research Article
Pages 323-331
Yoshihisa Kudo, Kyoko Nakamura, Kunie Sugaya, Kaori Noguchi, Toshio Iijima, Akihiko Ogura

Chapter 40: Muscarinic receptor subtype-specific coupling to second messengers in neuronal systems Original Research Article
Pages 333-340
Michael McKinney

Chapter 41: Modulation of information processing in thalamocortical systems: Chairman's introductory remarks Original Research Article
Pages 341-343
Mircea Steriade

Chapter 42: Cholinergic blockage of network- and intrinsically generated slow oscillations promotes waking and REM sleep activity patterns in thalamic and cortical neurons Original Research Article
Pages 345-355
Mircea Steriade

Chapter 43: Cholinergic modulation of sensory information Original Research Article
Pages 357-364
D.D. Rasmusson

Chapter 44: Cholinergic and glutamatergic effects on neocortical neurons may support rate as well as development of conditioning Original Research Article
Pages 365-370
C.D. Woody, E. Gruen

Chapter 45: The cholinergic neuromodulatory system: an evaluation of its functional roles Original Research Article
Pages 371-378
A.M. Sillito

Chapter 46: Cholinergic receptor subtypes and REM sleep in animals and normal controls Original Research Article
Pages 379-387
J. Christian Gillin, Rafael Salin-Pascual, Javier Velazquez-Moctezuma, Peter Shiromani, Rebecca Zoltoski

Chapter 47: Acetylcholine as a brain state modulator: triggering and long-term regulation of REM sleep Original Research Article
Pages 389-404
J.A. Hobson, S. Datta, J.M. Calvo, J. Quattrochi

Chapter 48: Behavioral aspects of cholinergic transmission: role of basal forebrain cholinergic system in learning and memory Original Research Article
Pages 405-411
Toshitaka Nabeshima

Chapter 49: Role of forebrain cholinergic systems in learning and memory: relevance to the cognitive deficits of aging and Alzheimer's dementia Original Research Article
Pages 413-420
S.B. Dunnett, H.C. Fibiger

Chapter 50: Clinical aspects of cholinergic pharmacology Original Research Article
Pages 421-422
Israel Hanin

Chapter 51: Approaches to cholinergic therapy in Alzheimer's disease Original Research Article
Pages 423-426
Leslie L. Iversen

Chapter 52: What have we learned from the THA trials to facilitate testing of new AChE inhibitors Original Research Article
Pages 427-429
S. Gauthier, L. Gauthier

Chapter 53: Brain selective inhibition of acetylcholinesterase: a novel approach to therapy for Alzheimer's disease Original Research Article
Pages 431-438
Albert Enz, Rene Amstutz, H. Boddeke, G. Gmelin, J. Malanowski

Chapter 54: Subtype selective muscarinic agonists: potential therapeutic agents for Alzheimer's disease Original Research Article
Pages 439-445
Robert Davis, Charlotte Raby, Michael J. Callahan, William Lipinski, Roy Schwarz, David T. Dudley, David Lauffer, Phillip Reece, Juan Jaen, Haile Tecle

Chapter 55: Pharmacotherapy of Alzheimer disease: new drugs and novel strategies Original Research Article
Pages 447-454
Ezio Giacobini

Chapter 56: Overview and future directions of CNS cholinergic mechanisms Original Research Article
Pages 455-458
Giancarlo Pepeu

Subject Index
Pages 459-462