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Dynamics and Equilibria for Oxidation of G, GG, and GGG Sequences in DNA Hairpins

✍ Scribed by Lewis, Frederick D.; Liu, Xiaoyang; Liu, Jianqin; Hayes, Ryan T.; Wasielewski, Michael R.


Book ID
126884761
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
35 KB
Volume
122
Category
Article
ISSN
0002-7863

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Oxidative damage to DNA by ionizing radiation, carcinogenic agents, and photosensitizers occurs predominately at guanine (G) bases, [1, 2] a result which can be rationalized by the hierarchy of in vitro oxidation potentials of the isolated nucleobases (G < A ( C,T). [3] Strand cleavage reactions, in