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Dynamics and diversions in base excision DNA repair of oxidized abasic lesions

✍ Scribed by Demple, Bruce; DeMott, Michael S


Book ID
110067299
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
211 KB
Volume
21
Category
Article
ISSN
0950-9232

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Endogenous oxidative damage to brain mitochondrial DNA and consequential disturbances of gene expression and mitochondrial dysfunction have long been implicated in aging and the pathogenesis of neurodegenerative diseases. It has yet to be determined, however, whether mitochondria in brain cells cont