Dynamic organization of pre-mRNA splicing factors

✍ Scribed by S. Huang; D.L. Spector

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 813 KB
• Volume: 62
• Category: Article
• ISSN: 0730-2312
• DOI: 10.1002/(sici)1097-4644(199608)62:2<191::aid-jcb7>3.0.co;2-n

✦ Synopsis

Studies from several laboratories during the past few years have increased our understanding towards the dynamic organization of pre-mRNA splicing factors in the mammalian cell nucleus. Many well characterized splicing factors have been localized in a speckled pattern in the cell nucleus. Upon the activation of RNA polymerase II transcription, splicing factors are recruited to the sites of transcription from sites of reassembly and/or storage. Nascent intron-containing RNA transcripts are spliced at the sites of transcription. The speckled distribution of splicing factors in the nucleus is altered when either transcription or pre-mRNA splicing activities are interrupted suggesting that the organization of the splicing machinery in the interphase nucleus is a direct reflection of the transcriptional activity of the Cell. c 1996Wiley-Liss, Inc.