Biochemical mechanisms of mammalian pre-mRNA splicing
β Scribed by Barbara Ruskin; Albrecht Bindereif; Kris Nelson; Claudio Pikielny; Phillip Zamore; Michael R. Green
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 57 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0301-4851
No coin nor oath required. For personal study only.
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Studies from several laboratories during the past few years have increased our understanding towards the dynamic organization of pre-mRNA splicing factors in the mammalian cell nucleus. Many well characterized splicing factors have been localized in a speckled pattern in the cell nucleus. Upon the a
Nuclear pre-mRNAs must be precisely processed to give rise to mature cytoplasmic mRNAs. This maturation process, known as splicing, involves excision of intron sequences and ligation of the exon sequences. One of the major problems in understanding this process is how splice sites, the sequences whi