Dynamic modelling, simulation and control of continuous adsorption recycle extraction

✍ Scribed by M.I. Rodrigues; C.A. Zaror; F. Maugeri; J.A. Asenjo

• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 641 KB
• Volume: 47
• Category: Article
• ISSN: 0009-2509
• DOI: 10.1016/0009-2509(92)80220-7

✦ Synopsis

A simple and effective process control scheme to regulate the continuous adsorption recycle extraction of proteins is presented. A dynamic mathematical model, based on unsteady mass balances, is derived and used in the study of the steady state and dynamic behaviour of the system, and to assist in the synthesis of appropriate control schemes. Sensitivity analysis show that performance is strongly affected by the feed flowrate and feed protein concentration. The eluent flowrate is shown to be the most suitable manipulated variable. The protein concentration in the product stream can be successfully controlled using a conventional PI feedback controller, when measurement time delays are not significant (less than 50% of sampling interval). Model-based feedforward compensation further improve-s performance in those cases where the main disturbances can be measured on-line in the feed stream. INTRODWXION Continuous adsorption recycle extraction was recently adapted for biotechnological applications as a downstream process for efficient separation of proteins from crude fcedstocks to be carried out continuously (Pungor et al., 1987; Gordon et al., 1990).

Modem biotechnology involves relatively small scale processes that favour batch procedures, usually following the concept that a batch is well defined (from beginning to end) and that this will pose fewer problems with regulatory approval for therapeutic