Dynamic kinetic resolution of racemic α-sulfonylaldehydes via asymmetric transfer hydrogenation

✍ Scribed by Guofeng Wu; Jinlong Zhu; Zhenhua Ding; Zongxuan Shen; Yawen Zhang

• Book ID: 104096021
• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 167 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.11.031

✦ Synopsis

Hydrogen transfer reduction of a-sulfonylaldehydes using HCOOH-Et 3 N system as hydrogen source and (S,S)-TsDPEN-based Ru(II) as catalyst proceeds with dynamic kinetic resolution, providing optically active b-sulfonyl primary alcohols in moderate-to-good yields and up to 90% ee.