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Dynamic Kinetic Resolution of N-Boc-2-lithiopyrrolidine.

✍ Scribed by Iain Coldham; Jignesh J. Patel; Graciela Sanchez-Jimenez


Publisher
John Wiley and Sons
Year
2005
Weight
18 KB
Volume
36
Category
Article
ISSN
0931-7597

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Asymmetric Substitutions of 2-Lithiated
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## Abstract Proton abstraction of __N__‐__tert__‐butoxycarbonyl‐piperidine (__N__‐Boc‐piperidine) with __s__BuLi and TMEDA provides a racemic organolithium that can be resolved using a chiral ligand. The enantiomeric organolithiums can interconvert so that a dynamic resolution occurs. Two mechanism