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Dynamic kinetic resolution

✍ Scribed by Moharem T El Gihani; Jonathan M.J Williams

Book ID
104415184
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
94 KB
Volume
3
Category
Article
ISSN
1367-5931

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✦ Synopsis

The use of transition-metal-enzyme combinations to effect tandem in situ racemisation and resolutions has extended the scope of dynamic kinetic resolutions. This methodology has signalled a more proactive stance to the racemisation process, which has traditionally relied on more fortuitous approaches, namely the exploitation of labile substrates. The development and application of specific racemising enzymes such as mandelate racemase offers potential for future multienzyme dynamic kinetic resolutions.

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The equilibration of a mixture of enantiomers or diastereoisomers prior Io or during kinetic resolution permits the isolation of a single isomer of one product in >50% yield. Examples of such processes involving bolh enantioselective and diastereoselective reactions are discussed. In some cases high