Dynamic kinetic resolution
β Scribed by Robert S. Ward
- Book ID
- 103977178
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 568 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0957-4166
No coin nor oath required. For personal study only.
β¦ Synopsis
The equilibration of a mixture of enantiomers or diastereoisomers prior Io or during kinetic resolution permits the isolation of a single isomer of one product in >50% yield. Examples of such processes involving bolh enantioselective and diastereoselective reactions are discussed. In some cases highly efficient processes are available, yielding, for example, cyanohydrin acetates and orsubstituted carboxylic acid derivatives in high yield and with high e.e. and d.e. respectively.
Contents
π SIMILAR VOLUMES
The use of transition-metal-enzyme combinations to effect tandem in situ racemisation and resolutions has extended the scope of dynamic kinetic resolutions. This methodology has signalled a more proactive stance to the racemisation process, which has traditionally relied on more fortuitous approache
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