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Dynamic HPLC on chiral stationary phases: A powerful tool for the investigation of stereomutation processes

✍ Scribed by Ilaria D'Acquarica; Francesco Gasparrini; Marco Pierini; Claudio Villani; Giovanni Zappia

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
887 KB
Volume
29
Category
Article
ISSN
1615-9306

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✦ Synopsis

Abstract

Dynamic HPLC on enantioselective stationary phases has become a well‐established technique to investigate chiral molecules with internal motions that result in stereoinversion and occur on the time scale of the separation process. Kinetic parameters for the on‐column interconversion phenomena can be extracted from experimental peak profiles by computer simulation or by direct calculation methods. The technique has been used in a wide range of temperatures and is complementary in scope to dynamic NMR spectroscopy.

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