Dynamic contrast-enhanced myocardial perfusion MRI accelerated with k-t sense

✍ Scribed by Sven Plein; Salome Ryf; Juerg Schwitter; Aleksandra Radjenovic; Peter Boesiger; Sebastian Kozerke

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 893 KB
• Volume: 58
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.21381

✦ Synopsis

Abstract

In the k‐t sensitivity encoding (k‐t SENSE) method spatiotemporal data correlations are exploited to accelerate data acquisition in dynamic MRI studies. The present study demonstrates the feasibility of applying k‐t SENSE to contrast‐enhanced myocardial perfusion MRI and using the speed‐up to increase spatial resolution. At a net acceleration factor of 3.9 (k‐t factor of 5 with 11 training profiles) accurate representations of dynamic signal intensity (SI) changes were achieved in computer simulations. In vivo, 5× k‐t SENSE was compared with 2× SENSE (identical acquisition parameters except for in‐plane spatial resolution = 1.48 × 1.48 mm^2^ vs. 2.64 × 2.64 mm^2^, respectively). In 10 volunteers no differences in myocardial SI profiles were found (relative peak enhancement = 151% vs. 149.7%, maximal upslope = 12.9%/s vs. 13.3%/s for 2× SENSE and 5× k‐t SENSE, respectively, all P > 0.05). Overall image quality was similar, but endocardial dark rim artifacts were reduced with k‐t SENSE. Signal‐to‐noise ratio (SNR) in the myocardium was greater with 5× k‐t SENSE by a factor of 1.36 ± 0.23 at peak contrast enhancement with the relative yield decreasing with increasing dynamics in the object in accordance to theory. Higher nominal acceleration factors of up to 10‐fold were shown to be feasible in computer simulations and in vivo. Magn Reson Med 58:777–785, 2007. © 2007 Wiley‐Liss, Inc.