Duchenne muscular dystrophy: Unusual activation of single fibers in vitro
β Scribed by Dr. Akio Takagi; Ikuya Nonaka
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 472 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0148-639X
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As the molecular basis of Duchenne Muscular Dystrophy (DMD) was being discovered, increasing focus was placed on the mechanisms of progressive failure of myoregeneration. In this study, we propose a pathogenesis model for DMD, where an autocrine growth factor release of TGF-β€1-from necrotic myofiber
## Abstract ## Background Targeted splice modulation of preβmRNA transcripts by antisense oligonucleotides (AOs) can correct the function of aberrant diseaseβrelated genes. Duchenne muscular dystrophy (DMD) arises as a result of mutations that interrupt the openβreading frame in the DMD gene encod
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